阿茲海默症是最常見的失智症類型，而磁振造影（MRI）在臨床診斷與疾病追蹤中可提供腦部結構變化之多面向資訊，包括大腦皮質萎縮（GCA）、內側顳葉萎縮（MTA）、白質高訊號（WMH）、以及腦部微出血（CMB）等。本研究納入確診AD患者與年齡匹配之對照組，進行腦部MRI掃描。影像特徵評估包含GCA、MTA、Fazekas白質高訊號分級與CMB分布。另以Syngo.Via影像處理系統進行量化分析，獲取海馬體體積、皮質厚度等客觀指標。統計分析採用雙尾檢定以比較AD與對照組之差異，並進一步探討影像特徵與臨床認知評估（如MMSE）之相關性。AD組顯示顯著之內側顳葉萎縮與皮質體積減少，白質高訊號與腦部微出血發生率亦高於對照組。Syngo.Via量化結果顯示，AD患者海馬體體積顯著縮小，且與MMSE分數呈正相關（p < 0.01）。MRI在AD之影像學評估中具有高度臨床價值，Syngo.Via系統提供之量化分析可補足傳統視覺評估之不足，並有助於疾病分期與追蹤。
Alzheimer's disease (AD) is the most common type of dementia, and neuroimaging plays a crucial role in diagnosis and monitoring. Magnetic Resonance Imaging (MRI) provides comprehensive structural information, including global cortical atrophy (GCA), medial temporal atrophy (MTA), white matter hyperintensities (WMH), and cerebral microbleeds (CMB). Patients with clinically diagnosed AD and age-matched controls underwent brain MRI examinations. Visual rating scales included GCA, MTA, Fazekas grading of WMH, and assessment of CMB. Quantitative volumetric analysis was performed using the Syngo.Via platform to measure hippocampal volume and cortical thickness. Group differences were assessed using two-tailed statistical tests, and correlations between imaging features and cognitive performance (Mini-Mental State Examination, MMSE) were analyzed. AD patients demonstrated significant medial temporal atrophy and cortical volume loss compared to controls. WMH burden and frequency of CMB were also higher in the AD group. Syngo.Via analysis revealed marked hippocampal volume reduction, which correlated positively with MMSE scores (p < 0.01). MRI provides valuable imaging biomarkers in AD evaluation. Quantitative analysis using Syngo.Via enhances diagnostic accuracy beyond traditional visual assessment and offers an objective approach for disease staging and longitudinal monitoring.
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